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KMID : 0371019790120010043
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Journal of Preventive Medicine and Public Health
1979 Volume.12 No. 1 p.43 ~ p.48
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A Study on the Urinary Lead Excretion after Oral D-penicillamine Administration
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Abstract
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For the purpose of further health control, D-penicillamine was orally administered to 8 persons who were employed in lead industry and suspected lead intoxication routine industrial health examination.
The does of D-penicillamine was 600 mg per day and was administered orally in every other 5 days. For the laboratory analysis 24 hours urine and 10 gm of whole blood were collected every day. The results were as follows;
1. It was found that mean urinary lead excretion per day was 44;65 g/I and 394.98 g/1, respectively during the first 5-day and the second 5-day administration with D-penicillamine.
2. Mean lead excretion per day was 13056 66.42 g/I after first 5-day administration and 159.28 104.44 g/I after second 5-day administration with D-penicillamine.
3. The level of urinary lead excretion after administration increased 3 to 4 times than that before administration with D-penicillamine.
4. Blood and urinary lead level investigated after 6 months were 44.4 + 10.2 g/100g and 72.7 29.7 g/I for the eight persons.
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